![]() Because of this difficulty, projection area length (PAL) is used to define the CC’s projection in the brain. 2, 8 The volume of structures like the CC, which are entirely composed of fibers, cannot be directly determined. The planimetric approach is the gold standard for clinicians’ assessments of neurological disorders. A planimetric procedure is one of the most reliable stereological methods. 7 Stereological methods can be used to analyze anatomical structures when it is impossible to remove organs and tissue. Several methods may be used to account for the total volumes of tissue, organs, and their components. These investigations use newly defined and more effective methods for determining the degeneration of cortical structures. 6 Lately, MRI investigations have indicated that patients with epilepsy may experience a degeneration of cortical structures. 3- 5 Neuroimaging techniques, such as MRI and CT, are increasingly used for examining anatomical structures and neuropsychological disorders, such as Alzheimer’s disease, dementia, and epilepsy. 5 In addition, the development of the CC might be altered by environmental factors and pathological changes. 4 In the literature, the CC is recognized as especially related to age, gender, brain functions, and neurologic diseases. The CC is the largest commissural pathway that interconnects the 2 hemispheres of the brain. Recent studies have shown us that a slimming of the CC is seen in patients with epilepsy. 3 The corpus callosum (CC) is the most important tract between cortical brain structures. 2 The relationship between the cortical brain structure with neuropsychological and neurophysiological events cannot be completely explained. Accumulating evidence has shown that TLE is a disorder of abnormal epileptogenic networks, rather than focal sources. Temporal lobe epilepsy (TLE) is the most common form of symptomatic and adult epilepsy it starts in the early childhood period. 1 Epileptic seizures are caused by changeable electric discharges in some neuron groups due to short-term brain function disorders. Epilepsy is associated with comprehensive neurological and metabolic disorders. ![]()
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